Organic Chemistry for Life Science

Developing new methodologies for the construction of a broad range of molecules significant in life sciences

Recent review articles

Recent original papers

Recent advances in the synthesis and transformations of sulfinate esters

S. Yoshida*

Chem. Commun. 2025, 61, 5084.

https://doi.org/10.1039/d5cc00797f

Recent advances in haloarene synthesis by aryne reactions

S. Tabata, S. Yoshida*

Tetrahedron Chem 2025, in press.

https://doi.org/10.1016/j.tchem.2025.100136

Regioselective pyridazine synthesis from tetrazines and alkynyl sulfides

C. Yamamoto, K. Numata, M. Suzuki, S. Yoshida*

Org. Chem. Front. 2024, 11, 6159.

https://doi.org/10.1039/D4QO01286K

Synthesis of Thiaphenanthridinones from Sulfinate Esters and 2-Borylanilines

K. Nakamura, M. Suzuki, S. Yoshida*

Org. Lett. 2024, 26, 9676

https://doi.org/10.1021/acs.orglett.4c03420

Three-step click assembly using trivalent platforms bearing azido, ethynyl, and fluorosulfonyl groups

T. Yasuda, G. Orimoto, S. Yoshida*

Chem. Commun. 2025, 61, 2333.

https://doi.org/10.1039/d4cc06585a

Thioxanthone Synthesis from Thioureas through Double Aryne Insertion into a Carbon-Sulfur Double Bond

M. Kawada, S. Tabata, Y. Hoshi, S. Yoshida*

Org. Lett. 2025, 27, 827.

(Most read articles (1 month))

https://doi.org/10.1021/acs.orglett.4c04490

Synthesis of multisubstituted naphthalenes through consecutive aryne reactions

T. Tanaka, S. Tabata, K. Nakamura, Y. Hazama, Y. Sakata, T. Hosoya, S. Yoshida*

Bull. Chem. Soc. Jpn. 2025, 98, uoaf001.

https://doi.org/10.1093/bulcsj/uoaf001

Conditional fluorescent changes of azaylides with fluorescent chromophores

M. Hamada, S. Yoshida*

Chem. Lett. 2025, 54, upaf033.

https://doi.org/10.1039/D4CC06769J

Facile Synthesis of Dibenzothiophene S-Oxides from Sulfinate Esters

Y. Kumagai, A. Kobayashi, K. Nakamura, S. Yoshida*

Chem. Commun. 2024, 60, 1611.

https://doi.org/10.1039/D3CC05703H

Highly substituted benzo[b]furan synthesis through substituent migration

A. Kobayashi, S. Tabata, S. Yoshida*

Chem. Commun. 2024, 60, 4545. (Selected as ChemComm HOT Articles)

https://doi.org/10.1039/D3CC05703H

Bromothiolation of Arynes for the Synthesis of 2-Bromobenzenethiol Equivalents

S. Tabata, S. Yoshida*

Org. Lett. 2024, 26, 3816.

https://doi.org/10.1021/acs.orglett.4c00944

Iterative click reactions using trivalent platforms for sequential molecular assembly

G. Orimoto, S. Yoshida*

Chem. Commun. 2024, 60, 4545.

https://doi.org/10.1039/D4CC01177E

Click assembly through selective azaylide formation

M. Hamada, G. Orimoto, S. Yoshida*

Chem. Commun. 2024, 60, 7930.

https://doi.org/10.1039/D4CC02723J

Synthesis of α-arylacetophenone derivatives by Grignard reactions and transformations of arynes via C–C bond cleavage

Y. Hoshi, S. Tabata, S. Yoshida*

Chem. Commun. 2025, 61, 3752.

https://doi.org/10.1039/D4CC06769J