Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

84

K. Kitakaze, S. Taniuchi, E. Kawano, Y. Hamada, M. Miyake, M. Oyadomari, H. Kojima, H. Kosako, T. Kuribara, S. Yoshida, T. Hosoya, *S. Oyadomari

Synthesis of Diverse γ-Aryl-β-ketoesters via Aryne Intermediates Generated by C–C Bond Cleavage

83

K. Uchida, Y. Minami, *S. Yoshida, *T. Hosoya

Org. Lett. 2019, 21, 9019.

https://doi.org/10.1021/acs.orglett.9b03418

東医歯大プレスリリース

Facile Synthesis of Diverse 2,6-Disubstituted Arylsilanes via Silylamination and Silylsulfanylation of Aryne Intermediates Generated from o-Iodoaryl Triflates

82

Y. Nakamura, S. Ozawa, *S. Yoshida, *T. Hosoya

Chem. Lett. 2019, 48, 1296.

https://doi.org/10.1246/cl.190573

Open Access

3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

81

Y. Nakamura, Y. Miyata, K. Uchida, *S. Yoshida,

*T. Hosoya

Org. Lett. 2019, 21, 5252.

https://doi.org/10.1021/acs.orglett.9b03418

東医歯大プレスリリース, 科学新聞(図入りハイライト)

Effect of Resonance on the Clickability of Alkenyl Azides in the Strain-promoted Cycloaddition with Dibenzo-fused Cyclooctynes

80

*S. Yoshida, S. Goto, Y. Nishiyama,Y. Hazama,  M. Kondo, T. Matsushita, *T. Hosoya

Chem. Lett. 2019, 48, 1038.

https://doi.org/10.1246/cl.190400

Open Access

Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates

79

K. Kanemoto, *S. Yoshida, and *T. Hosoya

Org. Lett. 2019, 21, 3172.

https://doi.org/10.1021/acs.orglett.9b00875

東医歯大プレスリリース; Most read article of OL in April 2019.

Facile Synthesis of Diverse o-Iodoaryl Triflates from o-Silylaryl Triflates by Aluminum-Mediated Desilyliodination

78

*S. Yoshida, Y. Hazama, K. Kanemoto, Y. Nakamura,

*T. Hosoya

Chem. Lett. 2019, 48, 742.

https://doi.org/10.1246/cl.190223

Open Access

Modular Synthesis of Unsymmetrical Doubly-ring-fused Benzene Derivatives Based on a Sequential Ring Construction Strategy Using Oxadiazinones as a Platform Molecule

77

T. Meguro, S. Chen, K. Kanemoto, *S. Yoshida, *T. Hosoya

Chem. Lett. 2019, 48, 582.

https://doi.org/10.1246/cl.190118

Open Access

Synthesis of Diverse 3-Azido-5-(azidomethyl)benzene Derivatives via Formal C–H Azidation and Functional Group-Selective Transformations

76

Y. Nishiyama, Y. Misawa, Y. Hazama, K. Oya, *S. Yoshida, *T. Hosoya

Heterocycles 2019, 99, 1366.

https://doi.org/10.3987/COM-18-S(F)72

Tohru Fukuyama’s Special Issues

A facile preparation of functional cycloalkynes by an azide-to-cycloalkyne switching approach

75

*S. Yoshida, T. Kuribara, H. Ito, T. Meguro, Y. Nishiyama,

F. Karaki, Y. Hatakeyama, Y. Koike, I. Kii, *T. Hosoya

Chem. Commun. 2019, 55, 3556.

https://doi.org/10.1039/C9CC01113G

Open Access; 東医歯大プレスリリース; 化学工業日報

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

74

Y. Toyoda, K. Morimoto, R. Suno, S. Horita, K. Yamashita, K. Hirata, Y. Sekiguchi, S. Yasuda, M. Shiroishi, T. Shimizu, Y. Urushibata, Y. Kajiwara, T. Inazumi, Y. Hotta, H. Asada, T. Nakane, Y. Shiimura, T. Nakagita, K. Tsuge, S. Yoshida, T. Kuribara, T. Hosoya, Y. Sugimoto, N. Nomura, M. Sato, T. Hirokawa, K. Masahiro, T. Murata, K. Takayama, M. Yamamoto, *S. Narumiya, *S. Iwata, and *T. Kobayashi

Nature Chem. Biol. 2019, 15, 18.

https://doi.org/10.1038/s41589-018-0131-3

Further enhancement of the clickability of doubly sterically-hindered aryl azides by para-amino substitution

73

S. Yoshida, J. Tanaka, Y. Nishiyama, Y. Hazama, T. Matsushita, *T. Hosoya

Chem. Commun. 2018, 54, 13499.

https://doi.org/10.1039/C8CC05791E

Open Access; Selected as inside back cover.

Generation of Arynes by Selective Cleavage of a Carbon–Phosphorus Bond of o-(Diarylphosphinyl)aryl Triflates Using a Grignard Reagent

72

Y. Nishiyama, S. Kamada, *S. Yoshida, *T. Hosoya

Chem. Lett. 2018, 47, 1216.

https://doi.org/10.1246/cl.180555

Open Access

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

71

T. Meguro, *S. Yoshida, K. Igawa, K. Tomooka, *T. Hosoya

Org. Lett. 2018, 20, 4126.

https://doi.org/10.1021/acs.orglett.8b01692

東医歯大プレスリリース; 日経産業新聞

Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors

70

*S. Yoshida, T. Kuribara, T. Morita, T. Matsuzawa,

K. Morimoto,  T. Kobayashi, *T. Hosoya

RSC Adv. 2018, 8, 21754.

https://doi.org/10.1039/C8RA04035D

Open Access

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

69

T. Meguro, N. Terashima, H. Ito, Y. Koike, I. Kii,

*S. Yoshida, and *T. Hosoya

Chem. Commun. 2018, 54, 7904.

https://doi.org/10.1039/C8CC00179K

Selected as back cover; Open Access; 東医歯大プレスリリース

Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with S-(o-Bromoaryl)-S-methylsulfilimines and Subsequent Intramolecular Buchwald–Hartwig Amination

68

T. Matsuzawa, K. Uchida, *S. Yoshida, *T. Hosoya

Chem. Lett. 2018, 47, 825.

https://doi.org/10.1246/cl.180304

Open Access

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

67

S. Yoshida, K. Kanno, I. Kii, Y. Misawa, M. Hagiwara,

*T. Hosoya

Chem. Commun. 2018, 54, 3705.

https://doi.org/10.1039/C8CC01195H

Selected as back cover; Open Access; 東医歯大プレスリリース

Modified Conditions for Copper-Catalyzed ipso-Thiolation of Arylboronic Acid Esters with Thiosulfonates

66

K. Kanemoto, *S. Yoshida, *T. Hosoya

Chem. Lett. 2018, 47, 85.

https://doi.org/10.1246/cl.170907

Open Access

Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory O-Arylation

65

T. Matsuzawa, K. Uchida, *S. Yoshida, *T. Hosoya

Org. Lett. 2017, 19, 5521.

https://doi.org/10.1021/acs.orglett.7b02599

東医歯大プレスリリース; 日経産業新聞

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

64

*S. Yoshida, K. Shimizu, K. Uchida, Y. Hazama, K. Igawa, K. Tomooka, *T. Hosoya

Chem. Eur. J. 2017, 23, 15332.

https://doi.org/10.1002/chem.201704345


Comparison of Pharmacokinetics of Newly Discovered Aromatase Inhibitors by A Cassette Microdosing Approach in Healthy Japanese Subjects

63

H. Kusuhara, T. Takashima, H. Fujii, T. Takashima,

M. Tanaka, A. Ishii, S. Tazawa, K. Takahashi, K. Takahashi,

H. Tokai, T. Yano, M. Kataoka, A. Inano, S. Yoshida,

T. Hosoya, Y. Sugiyama, S. Yamashita, T. Hojo,

*Y. Watanabe

Drug Metab. Pharmacokinet. 2017, 32, 293.

https://doi.org/10.1016/j.dmpk.2017.09.003

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates

62

K. Kanemoto, Y. Sugimura, S. Shimizu, *S. Yoshida,

*T. Hosoya

Chem. Commun. 2017, 53, 10640.

https://doi.org/10.1039/C7CC05868C

Selected as back cover; Open Access

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

61

A. Nakano-Kobayashi, T. Awaya, I. Kii, Y. Sumida,

Y. Okuno, S. Yoshida, T. Sumida, H. Inoue, T. Hosoya,

*M. Hagiwara

Proc. Natl. Acad. Sci. USA 2017, 114, 10268.

https://doi.org/10.1073/pnas.1704143114

Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents

60

Y. Nishiyama, Y. Hazama, *S. Yoshida, *T. Hosoya

Org. Lett. 2017, 19, 3899.

https://doi.org/10.1021/acs.orglett.7b01796

Highlighted in Synfacts; 東医歯大プレスリリース

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

59

Y. Sako, K. Ninomiya, Y. Okuno, M. Toyomoto, A. Nishida, Y. Koike, K. Ohe, I. Kii, S. Yoshida, N. Hashimoto,

T. Hosoya, M. Matsuo, *M. Hagiwara

Sci. Rep. 2017, 7, 46126.

https://doi.org/10.1038/srep46126

Open Access

Sequential Molecular Conjugation using Thiophene S,S-Dioxides Bearing a Clickable Functional Group

58

T. Meguro, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 1137.

https://doi.org/10.1246/cl.170426

Selected as Editor’s choice; Open Access

Facile Synthesis of Phthalides from Methyl ortho-Iodobenzoates and Ketones via an Iodine–Magnesium Exchange Reaction Using a Silylmethyl Grignard Reagent

57

Y. Nakamura, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 858.

https://doi.org/10.1246/cl.170211

Open Access

Enhancing the Synthetic Utility of 3-Haloaryne Intermediates by their Efficient Generation from Readily Synthesizable ortho-Iodoaryl Triflate-type Precursors

56

*S. Yoshida, A. Nagai, K. Uchida, *T. Hosoya

Chem. Lett. 2017, 46, 733.

https://doi.org/10.1246/cl.170136

Open Access

Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon–Carbon Bond Cleavage

55

K. Uchida, *S. Yoshida, *T. Hosoya

Org. Lett. 2017, 19, 1184.

https://doi.org/10.1021/acs.orglett.7b00242

東医歯大プレスリリース; ChemStation;

Academist Journal; 科学新聞

Aromatic Azido-selective Reduction via the Staudinger Reaction Using Tri-n-butylphosphonium Tetrafluoroborate with Triethylamine

54

T. Meguro, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 473.

https://doi.org/10.1246/cl.161159

Open Access

Facile Synthesis of Multisubstituted Benzo[b]furans via 2,3-Disubstituted 6,7-Furanobenzynes Generated from ortho-Iodoaryl Triflate-type Precursors

53

T. Morita, Y. Nishiyama, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 118.

https://doi.org/10.1246/cl.160951

Selected as Editor’s choice; Open Access

Facile Diversification of Simple Benzo[b]thiophenes via Thienobenzyne Intermediates

52

T. Morita, *S. Yoshida, M. Kondo, T. Matsushita,

*T. Hosoya

Chem. Lett. 2017, 46, 81.

https://doi.org/10.1246/cl.160901

Open Access

Reactions of Arynes with Sulfoximines: Formal Sulfinylamination vs N-Arylation

51

*S. Yoshida, H. Nakajima, K. Uchida, T. Yano, M. Kondo,

T. Matsushita, *T. Hosoya

Chem. Lett. 2017, 46, 77.

https://doi.org/10.1246/cl.160865

Open Access

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

50

*S. Yoshida, Y. Nakamura, K. Uchida, Y. Hazama,

*T. Hosoya

Org. Lett. 2016, 18, 6212.

https://doi.org/10.1021/acs.orglett.6b03304

Highlighted in Synfacts

The mevalonate pathway regulates primitive streak formation via protein farnesylation

49

Y. Okamoto-Uchida, R. Yu, N. Miyamura, N. Arima, M. Ishigami-Yuasa, H. Kagechika, S. Yoshida, T. Hosoya, M. Nawa, T. Kasama, Y. Asaoka, R. W. Alois, U. Elling, J. M. Penninger, S. Nishina, N. Azuma, *H. Nishina

Sci. Rep. 2016, 6, 37697.

https://doi.org/10.1038/srep37697

Open Access

Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles

48

S. Yoshida, T. Yano, Y. Nishiyama, Y. Misawa, M. Kondo,

T. Matsushita, K. Igawa, K. Tomooka, *T. Hosoya

Chem. Commun. 2016, 52, 11199.

https://doi.org/10.1039/C6CC05112J

Selected as inside back cover

Controlled Generation of 3-Triflyloxyarynes

47

K. Uchida, *S. Yoshida, *T. Hosoya

Single C–F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group

46

*S. Yoshida, K. Shimomori, Y. Kim, *T. Hosoya

Angew. Chem., Int. Ed. 2016, 55, 10406.

https://doi.org/10.1002/anie.201604776

Selected as hot paper and inside cover;

東医歯大プレスリリース; 日刊工業新聞

Synthesis of Diverse Benzotriazoles from Aryne Precursors Bearing an Azido Group via Inter- and Intramolecular Cycloadditions

45

S. Yoshida, T. Morita, *T. Hosoya

Chem. Lett. 2016, 45, 726.

https://doi.org/10.1246/cl.160349

Selected as Editor’s choice; Open Access

Selective inhibition of the kinase DYRK1A by targeting its folding process

44

*I. Kii, Y. Sumida, T. Goto, R. Sonamoto, Y. Okuno, S. Yoshida, T. Kato-Sumida, Y. Koike, M. Abe, Y. Nonaka, T. Ikura, N. Ito, H. Shibuya, T. Hosoya, *M. Hagiwara

Nature Commun. 2016, 7, 11391.

https://doi.org/10.1038/ncomms11391

Open Access

Publication

原著論文 (2020以降 / 2019~2016 / 2015以前)/総説・著書など特許