Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation


S. Yoshida, T. Yano, Y. Misawa, Y. Sugimura, K. Igawa,

S. Shimizu, K. Tomooka, *T. Hosoya

J. Am. Chem. Soc. 2015, 137, 14071.

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates


*S. Yoshida, Y. Sugimura, Y. Hazama, Y. Nishiyama,

T. Yano, S. Shimizu, *T. Hosoya

Chem. Commun. 2015, 51, 16613.

Selected as inside back cover; Highlighted in Chemistry View

Concise Synthesis of v-Coelenterazines


*T. Hosoya, R. Iimori, S. Yoshida, Y. Sumida,

Y. Sahara-Miura, J.-i. Sato, S. Inouye

Facile Synthesis of Diverse Multisubstituted ortho-Silylaryl Triflates via C–H Borylation


S. Yoshida, K. Shimomori, T. Nonaka, *T. Hosoya

Chem. Lett. 2015, 44, 1324.

Open Access

An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether


S. Yoshida, Y. Hazama, Y. Sumida, T. Yano,

*T. Hosoya

Molecules 2015, 20, 10131.

Special Issue: Development and Application of Aryne Chemistry in Organic Synthesis; Open Access

Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice


S. Morooka, M. Hoshina, I. Kii, T. Okabe, H. Kojima, N. Inoue, Y. Okuno, M. Denawa, S. Yoshida, J. Fukuhara, K. Ninomiya, T. Ikura, T. Furuya, T. Nagano, K. Noda, S. Ishida, T. Hosoya, N. Ito, N. Yoshimura, and *M. Hagiwara

Mol. Pharmacol. 2015, 88, 316.

Generation of cycloheptynes and cyclooctynes via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates


S. Yoshida, F. Karaki, K. Uchida, *T. Hosoya

Chem. Commun. 2015, 51, 8745.

Selected as inside front cover

Generation of Arynes Using Trimethylsilylmethyl Grignard Reagent for Activation of ortho-Iodoaryl or ortho-Sulfinylaryl Triflates


S. Yoshida, K. Uchida, *T. Hosoya

Chem. Lett. 2015, 44, 691.

Open Access

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia


M. Yoshida, N. Kataoka, K. Miyauchi, K. Ohe, K. Iida, S. Yoshida, T. Nojima, Y. Okuno, H. Onogi, T. Usui, A. Takeuchi, T. Hosoya, T. Suzuki, *M. Hagiwara

Proc. Natl. Acad. Sci. USA  2015, 112, 2764

Substituted 5,6,11,12-Tetradehydrodibenzo[a,e]cyclooctenes: Syntheses, Properties, and DFT Studies of Substituted Sondheimer–Wong Diynes


F. Xu, L. Peng, K. Shinohara, T. Morita, S. Yoshida,

T. Hosoya, *A. Orita, J. Otera

J. Org. Chem. 2014, 79, 11592.

An Efficient generation method and remarkable reactivities of 3-triflyloxybenzyne


S. Yoshida, K. Uchida, K. Igawa, K. Tomooka, *T. Hosoya

Chem. Commun. 2014, 50, 15059.

Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper


*S. Yoshida, Y. Hatakeyama, K. Johmoto, H. Uekusa,

*T. Hosoya

J. Am. Chem. Soc. 2014, 136, 13590.

Highlighted in Nature Chem., Organometallic News,

and Org. Chem. Highlights

Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide–aryne and azide–alkyne cycloadditions


S. Yoshida, T. Nonaka, T. Morita, *T. Hosoya

Org. Biomol. Chem. 2014, 12, 7489.

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses


M. Yamamoto, H. Onogi, I. Kii, S. Yoshida, K. Iida,

H. Sakai, M. Abe, T. Tsubota, N. Ito, T. Hosoya,

*M. Hagiwara

J. Clin. Investig. 2014, 124, 3479.

Formal C–H-Azidation-Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes


S. Yoshida, Y. Misawa, *T. Hosoya

Eur. J. Org. Chem. 2014, 3991

Generation of Arynes Triggered by the Sulfoxide–Metal Exchange Reaction of ortho-Sulfinylaryl Triflates


S. Yoshida, K. Uchida, *T. Hosoya

Chem. Lett. 2014, 43, 116.

Open Access

Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions


*S. Inouye, J.-i. Sato, Y. Sahara–Miura, S. Yoshida,

H. Kurakata, *T. Hosoya

Biochemi. Biophys. Res. Commun. 2014, 445, 157.

A New Organic Two-Electron Oxidant: 9,10-Diaryl-9,10-dihydroanthracene-9,10-bis(ylium)


*J. Ichikawa, H. Tanabe, S. Yoshida, T. Kawai, M. Shinjo, T. Fujita

Chem. Asian J. 2013, 8, 2588.

Development of bis-unsaturated ester aldehydes as amino-glue probes: Sequential double azaelectrocyclization as promising strategy for bioconjugation


*K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, *K. Fukase

Org. Biomol. Chem. 2013, 11, 7326.

C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase


*S. Inouye, J.-i. Sato, Y. Sahara–Miura, S. Yoshida,

H. Kurakata, *T. Hosoya

Biochem. Biophys. Res. Commun. 2013, 437, 23.

Synthesis of diverse aromatic oxophosphorus compounds by the Michaelis–Arbuzov-type reaction of arynes


S. Yoshida, *T. Hosoya

Chem. Lett. 2013, 42, 583.

Open Access

Copper-Catalyzed Extended Pummerer Reactions of Ketene Dithioacetal Monoxides with Alkynyl Sulfides and Ynamides with an Accompanying Oxygen Rearrangement


K. Murakami, J. Imoto, H. Matsubara, S. Yoshida,

*H. Yorimitsu, *K. Oshima

Chem. Eur. J. 2013, 23, 5625.

Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: Comparison of substrate specificity for C2-modified coelenterazines


*S. Inouye, Y. Sahara–Miura, J.-i. Sato, R. Iimori,

S. Yoshida, *T. Hosoya

Protein Expr. Purif. 2013, 88, 150.

Nucleophilic Substitution Reaction at the Nitrogen of Arylsulfonamides with Phosphide Anion


S. Yoshida, K. Igawa, *K. Tomook

J. Am. Chem. Soc. 2012, 134, 19358.

Highlighted in ChemASAP

Palladium-Catalyzed Regio- and Stereoselective Hydrosilylation of Electron-Deficient Alkynes


*Y. Sumida, T. Kato, S. Yoshida, *T. Hosoya

Org. Lett. 2012, 14, 1552.

Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation


D. Sakai, I. Kii, K. Nakagawa, H. N. Matsumoto, M. Takahashi, S. Yoshida, T. Hosoya, K. Takakuda, *A. Kudo

Enhanced clickability of doubly sterically-hindered aryl azides


S. Yoshida, A. Shiraishi, K. Kanno, T. Matsushita,

K. Johmoto, H. Uekusa, *T. Hosoya

Sci. Rep. 2011, 1, 82.

Open Access

Intermolecular Reductive Radical Addition to 2-(2,2,2-Trifluoroethylidene)-1,3-dithiane 1-Oxide: Experimental and Theoretical Studies


R. Nakayama, H. Matsubara, D. Fujino, T. Kobatake,

S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2010, 12, 5748.

Synthesis of 3-Trifluoromethylbenzo[b]furans from Phenols via Direct Ortho Functionalization by Extended Pummerer Reaction


T. Kobatake, D. Fujino, S. Yoshida, *H. Yorimitsu,

*K. Oshima

J. Am. Chem. Soc. 2010, 132, 11838.

Highlighted in Synfacts and Org. Proc. Res. Dev.

Strain-promoted double-click reaction for chemical modification of azido-biomolecules


I. Kii, A. Shiraishi, T. Hiramatsu, T. Matsushita, H. Uekusa,

S. Yoshida, M. Yamamoto, A. Kudo, M. Hagiwara, *T. Hosoya

Org. Biomol. Chem. 2010, 8, 4051.

Selected as inside front cover.

Reaction of 2-(2,2,2-Trifluoroethylidene)-1,3-dithiane 1-Oxide with Ketones under Pummerer Conditions and Its Application to the Synthesis of Trifluoromethyl-Substituted Five-Membered Heteroaromatics


T. Kobatake, S. Yoshida, *H. Yorimitsu, *K. Oshima

Angew. Chem., Int. Ed. 2010, 49, 2340.

Highlighted in Org. Proc. Res. Dev.

Tin-Hydride-Mediated Radical Addition of Alkyl Halides to 2-Methylene-1,3-dithiane Monoxide as a Ketene Equivalent


S. Yoshida, *H. Yorimitsu, *K. Oshima

Heterocycles 2010, 80, 259.

Palladium-catalyzed Mizoroki–Heck Reactions of 2-Methylene-1,3-dithiane 1-Oxide with Aryl Iodides


E. Morita, M. Iwasaki, S. Yoshida, *H. Yorimitsu,

*K. Oshima

Chem. Lett. 2009, 38, 624.

2-(2,2,2-Trifluoroethylidene)-1,3-dithiane Monoxide as a Trifluoromethylketene Equivalent


S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2009, 11, 2185.

Highlighted in Synfacts

Radical Addition of Alkyl Halides to 2-Methylene-1,3-dithiane Monoxide as a Ketene Equivalent


S. Yoshida, *H. Yorimitsu, *K. Oshima

Chem. Lett. 2009, 8, 248.

2-Alkylidene-1,3-dithiane Monoxides as Activated Alkenes in Rhodium-Catalyzed Addition Reaction of Arylboronic Acids


S. Yoshida, *H. Yorimitsu, *K. Oshima

Heterocycles 2008, 76, 679.

Synthesis of Bulky Arylphosphanes by Rhodium-Catalyzed Formal [2+2+2] Cycloaddition Reaction and Their Use as Ligands


T. Kobatake, A. Kondoh, S. Yoshida, *H. Yorimitsu,

*K. Oshima

Chem. Asian J. 2008, 3, 1613.

Extended Pummerer Reaction of Arylketene Dithioacetal Monoxides with Aromatic Compounds by Means of Trifluoromethanesulfonic Anhydride


S. Yoshida, *H. Yorimitsu, *K. Oshima

Chem. Lett. 2008, 37, 786.

Synthesis of Benzo[b]thiophenes by Cyclization of Arylketene Dithioacetal Monoxides under Pummerer-like Conditions


S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2007, 9, 5573.

Zirconocene-Catalyzed Alkylative Dimerization of 2-Methylene-1,3-dithiane via a Single Electron Transfer Process to Provide Symmetrical vic-Bis(dithiane)s


S. Yoshida, *H. Yorimitsu, *K. Oshima

J. Organomet. Chem. 2007, 692, 3110.

Rhodium-Catalyzed Addition of Arylboronic Acids to 2-Methylene-1,3-dithiane Monoxide


S. Yoshida, *H. Yorimitsu, *K. Oshima

Synlett 2007, 1622.

Naphthalene-1,8-diylbis(diphenylmethylium) as an Organic Two-Electron Oxidant: Benzidine Synthesis via Oxidative Self-Coupling of N,N-Dialkylanilines


T. Saitoh, S. Yoshida, *J. Ichikawa

J. Org. Chem. 2006, 71, 6414.

1,8-Bis(diphenylmethylium)naphthalenediyl Dication as an Organic Oxidant: Synthesis of Benzidines via Self-Coupling of N,N-Dialkylanilines


T. Saitoh, S. Yoshida, *J. Ichikawa

Orga. Lett. 2004, 6, 4563.


原著論文 (2020以降 / 2019~2016 / 2015以前)/総説・著書など特許