Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

◆ 84

K. Kitakaze, S. Taniuchi, E. Kawano, Y. Hamada, M. Miyake, M. Oyadomari, H. Kojima, H. Kosako, T. Kuribara, S. Yoshida, T. Hosoya, *S. Oyadomari

Synthesis of Diverse γ-Aryl-β-ketoesters via Aryne Intermediates Generated by C–C Bond Cleavage

◆ 83

K. Uchida, Y. Minami, *S. Yoshida, *T. Hosoya

Facile Synthesis of Diverse 2,6-Disubstituted Arylsilanes via Silylamination and Silylsulfanylation of Aryne Intermediates Generated from o-Iodoaryl Triflates

◆ 82

Y. Nakamura, S. Ozawa, *S. Yoshida, *T. Hosoya

Chem. Lett. 2019, 48, 1296.

https://doi.org/10.1246/cl.190573

Open Access

3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

◆ 81

Y. Nakamura, Y. Miyata, K. Uchida, *S. Yoshida,

*T. Hosoya

Effect of Resonance on the Clickability of Alkenyl Azides in the Strain-promoted Cycloaddition with Dibenzo-fused Cyclooctynes

◆ 80

*S. Yoshida, S. Goto, Y. Nishiyama,Y. Hazama,  M. Kondo, T. Matsushita, *T. Hosoya

Chem. Lett. 2019, 48, 1038.

https://doi.org/10.1246/cl.190400

Open Access

Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates

◆ 79

K. Kanemoto, *S. Yoshida, and *T. Hosoya

Org. Lett. 2019, 21, 3172.

https://doi.org/10.1021/acs.orglett.9b00875

Most read article of OL in April 2019.

Facile Synthesis of Diverse o-Iodoaryl Triflates from o-Silylaryl Triflates by Aluminum-Mediated Desilyliodination

◆ 78

*S. Yoshida, Y. Hazama, K. Kanemoto, Y. Nakamura,

*T. Hosoya

Chem. Lett. 2019, 48, 742.

https://doi.org/10.1246/cl.190223

Open Access

Modular Synthesis of Unsymmetrical Doubly-ring-fused Benzene Derivatives Based on a Sequential Ring Construction Strategy Using Oxadiazinones as a Platform Molecule

◆ 77

T. Meguro, S. Chen, K. Kanemoto, *S. Yoshida, *T. Hosoya

Chem. Lett. 2019, 48, 582.

https://doi.org/10.1246/cl.190118

Open Access

Synthesis of Diverse 3-Azido-5-(azidomethyl)benzene Derivatives via Formal C–H Azidation and Functional Group-Selective Transformations

◆ 76

Y. Nishiyama, Y. Misawa, Y. Hazama, K. Oya, *S. Yoshida, *T. Hosoya

Heterocycles 2019, 99, 1366.

https://doi.org/10.3987/COM-18-S(F)72

Tohru Fukuyama’s Special Issues

A facile preparation of functional cycloalkynes by an azide-to-cycloalkyne switching approach

◆ 75

*S. Yoshida, T. Kuribara, H. Ito, T. Meguro, Y. Nishiyama,

F. Karaki, Y. Hatakeyama, Y. Koike, I. Kii, *T. Hosoya

Chem. Commun. 2019, 55, 3556.

https://doi.org/10.1039/C9CC01113G

Open Access

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

◆ 74

Y. Toyoda, K. Morimoto, R. Suno, S. Horita, K. Yamashita, K. Hirata, Y. Sekiguchi, S. Yasuda, M. Shiroishi, T. Shimizu, Y. Urushibata, Y. Kajiwara, T. Inazumi, Y. Hotta, H. Asada, T. Nakane, Y. Shiimura, T. Nakagita, K. Tsuge, S. Yoshida, T. Kuribara, T. Hosoya, Y. Sugimoto, N. Nomura, M. Sato, T. Hirokawa, K. Masahiro, T. Murata, K. Takayama, M. Yamamoto, *S. Narumiya, *S. Iwata, and *T. Kobayashi

Nature Chem. Biol. 2019, 15, 18.

https://doi.org/10.1038/s41589-018-0131-3

Further enhancement of the clickability of doubly sterically-hindered aryl azides by para-amino substitution

◆ 73

S. Yoshida, J. Tanaka, Y. Nishiyama, Y. Hazama, T. Matsushita, *T. Hosoya

Chem. Commun. 2018, 54, 13499.

https://doi.org/10.1039/C8CC05791E

Open Access; Selected as inside back cover.

Generation of Arynes by Selective Cleavage of a Carbon–Phosphorus Bond of o-(Diarylphosphinyl)aryl Triflates Using a Grignard Reagent

◆ 72

Y. Nishiyama, S. Kamada, *S. Yoshida, *T. Hosoya

Chem. Lett. 2018, 47, 1216.

https://doi.org/10.1246/cl.180555

Open Access

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

◆ 71

T. Meguro, *S. Yoshida, K. Igawa, K. Tomooka, *T. Hosoya

Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors

◆ 70

*S. Yoshida, T. Kuribara, T. Morita, T. Matsuzawa,

K. Morimoto,  T. Kobayashi, *T. Hosoya

RSC Adv. 2018, 8, 21754.

https://doi.org/10.1039/C8RA04035D

Open Access

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

◆ 69

T. Meguro, N. Terashima, H. Ito, Y. Koike, I. Kii,

*S. Yoshida, and *T. Hosoya

Chem. Commun. 2018, 54, 7904.

https://doi.org/10.1039/C8CC00179K

Selected as back cover; Open Access

Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with S-(o-Bromoaryl)-S-methylsulfilimines and Subsequent Intramolecular Buchwald–Hartwig Amination

◆ 68

T. Matsuzawa, K. Uchida, *S. Yoshida, *T. Hosoya

Chem. Lett. 2018, 47, 825.

https://doi.org/10.1246/cl.180304

Open Access

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

◆ 67

S. Yoshida, K. Kanno, I. Kii, Y. Misawa, M. Hagiwara,

*T. Hosoya

Chem. Commun. 2018, 54, 3705.

https://doi.org/10.1039/C8CC01195H

Selected as back cover; Open Access

Modified Conditions for Copper-Catalyzed ipso-Thiolation of Arylboronic Acid Esters with Thiosulfonates

◆ 66

K. Kanemoto, *S. Yoshida, *T. Hosoya

Chem. Lett. 2018, 47, 85.

https://doi.org/10.1246/cl.170907

Open Access

Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory O-Arylation

◆ 65

T. Matsuzawa, K. Uchida, *S. Yoshida, *T. Hosoya

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

◆ 64

*S. Yoshida, K. Shimizu, K. Uchida, Y. Hazama, K. Igawa, K. Tomooka, *T. Hosoya

Chem. Eur. J. 2017, 23, 15332.

https://doi.org/10.1002/chem.201704345


Comparison of Pharmacokinetics of Newly Discovered Aromatase Inhibitors by A Cassette Microdosing Approach in Healthy Japanese Subjects

◆ 63

H. Kusuhara, T. Takashima, H. Fujii, T. Takashima,

M. Tanaka, A. Ishii, S. Tazawa, K. Takahashi, K. Takahashi,

H. Tokai, T. Yano, M. Kataoka, A. Inano, S. Yoshida,

T. Hosoya, Y. Sugiyama, S. Yamashita, T. Hojo,

*Y. Watanabe

Drug Metab. Pharmacokinet. 2017, 32, 293.

https://doi.org/10.1016/j.dmpk.2017.09.003

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates

◆ 62

K. Kanemoto, Y. Sugimura, S. Shimizu, *S. Yoshida,

*T. Hosoya

Chem. Commun. 2017, 53, 10640.

https://doi.org/10.1039/C7CC05868C

Selected as back cover; Open Access

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

◆ 61

A. Nakano-Kobayashi, T. Awaya, I. Kii, Y. Sumida,

Y. Okuno, S. Yoshida, T. Sumida, H. Inoue, T. Hosoya,

*M. Hagiwara

Proc. Natl. Acad. Sci. USA 2017, 114, 10268.

https://doi.org/10.1073/pnas.1704143114

Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents

◆ 60

Y. Nishiyama, Y. Hazama, *S. Yoshida, *T. Hosoya

Org. Lett. 2017, 19, 3899.

https://doi.org/10.1021/acs.orglett.7b01796

Highlighted in Synfacts

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

◆ 59

Y. Sako, K. Ninomiya, Y. Okuno, M. Toyomoto, A. Nishida, Y. Koike, K. Ohe, I. Kii, S. Yoshida, N. Hashimoto,

T. Hosoya, M. Matsuo, *M. Hagiwara

Sci. Rep. 2017, 7, 46126.

https://doi.org/10.1038/srep46126

Open Access

Sequential Molecular Conjugation using Thiophene S,S-Dioxides Bearing a Clickable Functional Group

◆ 58

T. Meguro, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 1137.

https://doi.org/10.1246/cl.170426

Selected as Editor’s choice; Open Access

Facile Synthesis of Phthalides from Methyl ortho-Iodobenzoates and Ketones via an Iodine–Magnesium Exchange Reaction Using a Silylmethyl Grignard Reagent

◆ 57

Y. Nakamura, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 858.

https://doi.org/10.1246/cl.170211

Open Access

Enhancing the Synthetic Utility of 3-Haloaryne Intermediates by their Efficient Generation from Readily Synthesizable ortho-Iodoaryl Triflate-type Precursors

◆ 56

*S. Yoshida, A. Nagai, K. Uchida, *T. Hosoya

Chem. Lett. 2017, 46, 733.

https://doi.org/10.1246/cl.170136

Open Access

Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon–Carbon Bond Cleavage

◆ 55

K. Uchida, *S. Yoshida, *T. Hosoya

Aromatic Azido-selective Reduction via the Staudinger Reaction Using Tri-n-butylphosphonium Tetrafluoroborate with Triethylamine

◆ 54

T. Meguro, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 473.

https://doi.org/10.1246/cl.161159

Open Access

Facile Synthesis of Multisubstituted Benzo[b]furans via 2,3-Disubstituted 6,7-Furanobenzynes Generated from ortho-Iodoaryl Triflate-type Precursors

◆ 53

T. Morita, Y. Nishiyama, *S. Yoshida, *T. Hosoya

Chem. Lett. 2017, 46, 118.

https://doi.org/10.1246/cl.160951

Selected as Editor’s choice; Open Access

Facile Diversification of Simple Benzo[b]thiophenes via Thienobenzyne Intermediates

◆ 52

T. Morita, *S. Yoshida, M. Kondo, T. Matsushita,

*T. Hosoya

Chem. Lett. 2017, 46, 81.

https://doi.org/10.1246/cl.160901

Open Access

Reactions of Arynes with Sulfoximines: Formal Sulfinylamination vs N-Arylation

◆ 51

*S. Yoshida, H. Nakajima, K. Uchida, T. Yano, M. Kondo,

T. Matsushita, *T. Hosoya

Chem. Lett. 2017, 46, 77.

https://doi.org/10.1246/cl.160865

Open Access

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

◆ 50

*S. Yoshida, Y. Nakamura, K. Uchida, Y. Hazama,

*T. Hosoya

Org. Lett. 2016, 18, 6212.

https://doi.org/10.1021/acs.orglett.6b03304

Highlighted in Synfacts

The mevalonate pathway regulates primitive streak formation via protein farnesylation

◆ 49

Y. Okamoto-Uchida, R. Yu, N. Miyamura, N. Arima, M. Ishigami-Yuasa, H. Kagechika, S. Yoshida, T. Hosoya, M. Nawa, T. Kasama, Y. Asaoka, R. W. Alois, U. Elling, J. M. Penninger, S. Nishina, N. Azuma, *H. Nishina

Sci. Rep. 2016, 6, 37697.

https://doi.org/10.1038/srep37697

Open Access

Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles

◆ 48

S. Yoshida, T. Yano, Y. Nishiyama, Y. Misawa, M. Kondo,

T. Matsushita, K. Igawa, K. Tomooka, *T. Hosoya

Chem. Commun. 2016, 52, 11199.

https://doi.org/10.1039/C6CC05112J

Selected as inside back cover

Controlled Generation of 3-Triflyloxyarynes

◆ 47

K. Uchida, *S. Yoshida, *T. Hosoya

Single C–F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group

◆ 46

*S. Yoshida, K. Shimomori, Y. Kim, *T. Hosoya

Angew. Chem., Int. Ed. 2016, 55, 10406.

https://doi.org/10.1002/anie.201604776

Selected as hot paper and inside cover

Synthesis of Diverse Benzotriazoles from Aryne Precursors Bearing an Azido Group via Inter- and Intramolecular Cycloadditions

◆ 45

S. Yoshida, T. Morita, *T. Hosoya

Chem. Lett. 2016, 45, 726.

https://doi.org/10.1246/cl.160349

Selected as Editor’s choice; Open Access

Selective inhibition of the kinase DYRK1A by targeting its folding process

◆ 44

*I. Kii, Y. Sumida, T. Goto, R. Sonamoto, Y. Okuno, S. Yoshida, T. Kato-Sumida, Y. Koike, M. Abe, Y. Nonaka, T. Ikura, N. Ito, H. Shibuya, T. Hosoya, *M. Hagiwara

Nature Commun. 2016, 7, 11391.

https://doi.org/10.1038/ncomms11391

Open Access

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