Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation

◆ 43

S. Yoshida, T. Yano, Y. Misawa, Y. Sugimura, K. Igawa,

S. Shimizu, K. Tomooka, *T. Hosoya

J. Am. Chem. Soc. 2015, 137, 14071.

https://doi.org/10.1021/jacs.5b10557

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates

◆ 42

*S. Yoshida, Y. Sugimura, Y. Hazama, Y. Nishiyama,

T. Yano, S. Shimizu, *T. Hosoya

Chem. Commun. 2015, 51, 16613.

https://doi.org/10.1039/C5CC07463K

Selected as inside back cover; Highlighted in Chemistry View

Concise Synthesis of v-Coelenterazines

◆ 41

*T. Hosoya, R. Iimori, S. Yoshida, Y. Sumida,

Y. Sahara-Miura, J.-i. Sato, S. Inouye

Facile Synthesis of Diverse Multisubstituted ortho-Silylaryl Triflates via C–H Borylation

◆ 40

S. Yoshida, K. Shimomori, T. Nonaka, *T. Hosoya

Chem. Lett. 2015, 44, 1324.

https://doi.org/10.1246/cl.150535

Open Access

An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether

◆ 39

S. Yoshida, Y. Hazama, Y. Sumida, T. Yano,

*T. Hosoya

Molecules 2015, 20, 10131.

https://doi.org/10.3390/molecules200610131

Special Issue: Development and Application of Aryne Chemistry in Organic Synthesis; Open Access

Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

◆ 38

S. Morooka, M. Hoshina, I. Kii, T. Okabe, H. Kojima, N. Inoue, Y. Okuno, M. Denawa, S. Yoshida, J. Fukuhara, K. Ninomiya, T. Ikura, T. Furuya, T. Nagano, K. Noda, S. Ishida, T. Hosoya, N. Ito, N. Yoshimura, and *M. Hagiwara

Mol. Pharmacol. 2015, 88, 316.

https://doi.org/10.1124/mol.114.097345

Generation of cycloheptynes and cyclooctynes via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates

◆ 37

S. Yoshida, F. Karaki, K. Uchida, *T. Hosoya

Chem. Commun. 2015, 51, 8745.

https://doi.org/10.1039/C5CC01784J

Selected as inside front cover

Generation of Arynes Using Trimethylsilylmethyl Grignard Reagent for Activation of ortho-Iodoaryl or ortho-Sulfinylaryl Triflates

◆ 36

S. Yoshida, K. Uchida, *T. Hosoya

Chem. Lett. 2015, 44, 691.

https://doi.org/10.1246/cl.150060

Open Access

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

◆ 35

M. Yoshida, N. Kataoka, K. Miyauchi, K. Ohe, K. Iida, S. Yoshida, T. Nojima, Y. Okuno, H. Onogi, T. Usui, A. Takeuchi, T. Hosoya, T. Suzuki, *M. Hagiwara

Proc. Natl. Acad. Sci. USA  2015, 112, 2764

https://doi.org/10.1073/pnas.1415525112


Substituted 5,6,11,12-Tetradehydrodibenzo[a,e]cyclooctenes: Syntheses, Properties, and DFT Studies of Substituted Sondheimer–Wong Diynes

◆ 34

F. Xu, L. Peng, K. Shinohara, T. Morita, S. Yoshida,

T. Hosoya, *A. Orita, J. Otera

J. Org. Chem. 2014, 79, 11592.

https://doi.org/10.1021/jo502248p

An Efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

◆ 33

S. Yoshida, K. Uchida, K. Igawa, K. Tomooka, *T. Hosoya

Chem. Commun. 2014, 50, 15059.

https://doi.org/10.1039/C4CC07058E

Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper

◆ 32

*S. Yoshida, Y. Hatakeyama, K. Johmoto, H. Uekusa,

*T. Hosoya

J. Am. Chem. Soc. 2014, 136, 13590.

https://doi.org/10.1021/ja507660x

Highlighted in Nature Chem., Organometallic News,

and Org. Chem. Highlights

Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide–aryne and azide–alkyne cycloadditions

◆ 31

S. Yoshida, T. Nonaka, T. Morita, *T. Hosoya

Org. Biomol. Chem. 2014, 12, 7489.

https://doi.org/10.1039/C4OB01654H

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

◆ 30

M. Yamamoto, H. Onogi, I. Kii, S. Yoshida, K. Iida,

H. Sakai, M. Abe, T. Tsubota, N. Ito, T. Hosoya,

*M. Hagiwara

J. Clin. Investig. 2014, 124, 3479.

https://doi.org/10.1172/JCI73805

Formal C–H-Azidation-Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes

◆ 29

S. Yoshida, Y. Misawa, *T. Hosoya

Eur. J. Org. Chem. 2014, 3991

https://doi.org/10.1002/ejoc.201402516

Generation of Arynes Triggered by the Sulfoxide–Metal Exchange Reaction of ortho-Sulfinylaryl Triflates

◆ 28

S. Yoshida, K. Uchida, *T. Hosoya

Chem. Lett. 2014, 43, 116.

https://doi.org/10.1246/cl.130899

Open Access

Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions

◆ 27

*S. Inouye, J.-i. Sato, Y. Sahara–Miura, S. Yoshida,

H. Kurakata, *T. Hosoya

Biochemi. Biophys. Res. Commun. 2014, 445, 157.

https://doi.org/10.1016/j.bbrc.2014.01.133

A New Organic Two-Electron Oxidant: 9,10-Diaryl-9,10-dihydroanthracene-9,10-bis(ylium)

◆ 26

*J. Ichikawa, H. Tanabe, S. Yoshida, T. Kawai, M. Shinjo, T. Fujita

Chem. Asian J. 2013, 8, 2588.

https://doi.org/10.1002/asia.201300710

Development of bis-unsaturated ester aldehydes as amino-glue probes: Sequential double azaelectrocyclization as promising strategy for bioconjugation

◆ 25

*K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, *K. Fukase

Org. Biomol. Chem. 2013, 11, 7326.

https://doi.org/10.1039/C3OB41507D

C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase

◆ 24

*S. Inouye, J.-i. Sato, Y. Sahara–Miura, S. Yoshida,

H. Kurakata, *T. Hosoya

Biochem. Biophys. Res. Commun. 2013, 437, 23.

https://doi.org/10.1016/j.bbrc.2013.06.026

Synthesis of diverse aromatic oxophosphorus compounds by the Michaelis–Arbuzov-type reaction of arynes

◆ 23

S. Yoshida, *T. Hosoya

Chem. Lett. 2013, 42, 583.

https://doi.org/10.1246/cl.130116

Open Access

Copper-Catalyzed Extended Pummerer Reactions of Ketene Dithioacetal Monoxides with Alkynyl Sulfides and Ynamides with an Accompanying Oxygen Rearrangement

◆ 22

K. Murakami, J. Imoto, H. Matsubara, S. Yoshida,

*H. Yorimitsu, *K. Oshima

Chem. Eur. J. 2013, 23, 5625.

https://doi.org/10.1002/chem.201204072

Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: Comparison of substrate specificity for C2-modified coelenterazines

◆ 21

*S. Inouye, Y. Sahara–Miura, J.-i. Sato, R. Iimori,

S. Yoshida, *T. Hosoya

Protein Expr. Purif. 2013, 88, 150.

https://doi.org/10.1016/j.pep.2012.12.006

Nucleophilic Substitution Reaction at the Nitrogen of Arylsulfonamides with Phosphide Anion

◆ 20

S. Yoshida, K. Igawa, *K. Tomook

J. Am. Chem. Soc. 2012, 134, 19358.

https://doi.org/10.1021/ja309642r

Highlighted in ChemASAP

Palladium-Catalyzed Regio- and Stereoselective Hydrosilylation of Electron-Deficient Alkynes

◆ 19

*Y. Sumida, T. Kato, S. Yoshida, *T. Hosoya

Org. Lett. 2012, 14, 1552.

https://doi.org/10.1021/ol300279c

Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation

◆ 18

D. Sakai, I. Kii, K. Nakagawa, H. N. Matsumoto, M. Takahashi, S. Yoshida, T. Hosoya, K. Takakuda, *A. Kudo

Enhanced clickability of doubly sterically-hindered aryl azides

◆ 17

S. Yoshida, A. Shiraishi, K. Kanno, T. Matsushita,

K. Johmoto, H. Uekusa, *T. Hosoya

Sci. Rep. 2011, 1, 82.

https://doi.org/10.1038/srep00082

Open Access

Intermolecular Reductive Radical Addition to 2-(2,2,2-Trifluoroethylidene)-1,3-dithiane 1-Oxide: Experimental and Theoretical Studies

◆ 16

R. Nakayama, H. Matsubara, D. Fujino, T. Kobatake,

S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2010, 12, 5748.

https://doi.org/10.1021/ol1025926


Synthesis of 3-Trifluoromethylbenzo[b]furans from Phenols via Direct Ortho Functionalization by Extended Pummerer Reaction

◆ 15

T. Kobatake, D. Fujino, S. Yoshida, *H. Yorimitsu,

*K. Oshima

J. Am. Chem. Soc. 2010, 132, 11838.

https://doi.org/10.1021/ja1030134

Highlighted in Synfacts and Org. Proc. Res. Dev.

Strain-promoted double-click reaction for chemical modification of azido-biomolecules

◆ 14

I. Kii, A. Shiraishi, T. Hiramatsu, T. Matsushita, H. Uekusa,

S. Yoshida, M. Yamamoto, A. Kudo, M. Hagiwara, *T. Hosoya

Org. Biomol. Chem. 2010, 8, 4051.

https://doi.org/10.1039/C3OB41507D

Selected as inside front cover.

Reaction of 2-(2,2,2-Trifluoroethylidene)-1,3-dithiane 1-Oxide with Ketones under Pummerer Conditions and Its Application to the Synthesis of Trifluoromethyl-Substituted Five-Membered Heteroaromatics

◆ 13

T. Kobatake, S. Yoshida, *H. Yorimitsu, *K. Oshima

Angew. Chem., Int. Ed. 2010, 49, 2340.

https://doi.org/10.1002/anie.200906774

Highlighted in Org. Proc. Res. Dev.

Tin-Hydride-Mediated Radical Addition of Alkyl Halides to 2-Methylene-1,3-dithiane Monoxide as a Ketene Equivalent

◆ 12

S. Yoshida, *H. Yorimitsu, *K. Oshima

Heterocycles 2010, 80, 259.

https://doi.org/10.3987/COM-09-S(S)6

Palladium-catalyzed Mizoroki–Heck Reactions of 2-Methylene-1,3-dithiane 1-Oxide with Aryl Iodides

◆ 11

E. Morita, M. Iwasaki, S. Yoshida, *H. Yorimitsu,

*K. Oshima

Chem. Lett. 2009, 38, 624.

https://doi.org/10.1246/cl.2009.624

2-(2,2,2-Trifluoroethylidene)-1,3-dithiane Monoxide as a Trifluoromethylketene Equivalent

◆ 10

S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2009, 11, 2185.

https://doi.org/10.1021/ol9004883

Highlighted in Synfacts

Radical Addition of Alkyl Halides to 2-Methylene-1,3-dithiane Monoxide as a Ketene Equivalent

◆ 9

S. Yoshida, *H. Yorimitsu, *K. Oshima

Chem. Lett. 2009, 8, 248.

https://doi.org/10.1246/cl.2009.248

2-Alkylidene-1,3-dithiane Monoxides as Activated Alkenes in Rhodium-Catalyzed Addition Reaction of Arylboronic Acids

◆ 8

S. Yoshida, *H. Yorimitsu, *K. Oshima

Heterocycles 2008, 76, 679.

https://doi.org/10.3987/COM-08-S(N)65

Synthesis of Bulky Arylphosphanes by Rhodium-Catalyzed Formal [2+2+2] Cycloaddition Reaction and Their Use as Ligands

◆ 7

T. Kobatake, A. Kondoh, S. Yoshida, *H. Yorimitsu,

*K. Oshima

Chem. Asian J. 2008, 3, 1613.

https://doi.org/10.1002/asia.200800102

Extended Pummerer Reaction of Arylketene Dithioacetal Monoxides with Aromatic Compounds by Means of Trifluoromethanesulfonic Anhydride

◆ 6

S. Yoshida, *H. Yorimitsu, *K. Oshima

Chem. Lett. 2008, 37, 786.

https://doi.org/10.1246/cl.2008.786

Synthesis of Benzo[b]thiophenes by Cyclization of Arylketene Dithioacetal Monoxides under Pummerer-like Conditions

◆ 5

S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2007, 9, 5573.

https://doi.org/10.1021/ol702643j


Zirconocene-Catalyzed Alkylative Dimerization of 2-Methylene-1,3-dithiane via a Single Electron Transfer Process to Provide Symmetrical vic-Bis(dithiane)s

◆ 4

S. Yoshida, *H. Yorimitsu, *K. Oshima

J. Organomet. Chem. 2007, 692, 3110.

https://doi.org/10.1016/j.jorganchem.2006.12.029

Rhodium-Catalyzed Addition of Arylboronic Acids to 2-Methylene-1,3-dithiane Monoxide

◆ 3

S. Yoshida, *H. Yorimitsu, *K. Oshima

Synlett 2007, 1622.

https://doi.org/10.1055/s-2007-980373

Naphthalene-1,8-diylbis(diphenylmethylium) as an Organic Two-Electron Oxidant: Benzidine Synthesis via Oxidative Self-Coupling of N,N-Dialkylanilines

◆ 2

T. Saitoh, S. Yoshida, *J. Ichikawa

J. Org. Chem. 2006, 71, 6414.

https://doi.org/10.1021/jo060662s


1,8-Bis(diphenylmethylium)naphthalenediyl Dication as an Organic Oxidant: Synthesis of Benzidines via Self-Coupling of N,N-Dialkylanilines

◆ 1

T. Saitoh, S. Yoshida, *J. Ichikawa

Orga. Lett. 2004, 6, 4563.

https://doi.org/10.1021/ol048058w

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