Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation

43

S. Yoshida, T. Yano, Y. Misawa, Y. Sugimura, K. Igawa,

S. Shimizu, K. Tomooka, *T. Hosoya

J. Am. Chem. Soc. 2015, 137, 14071.

https://doi.org/10.1021/jacs.5b10557

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates

42

*S. Yoshida, Y. Sugimura, Y. Hazama, Y. Nishiyama,

T. Yano, S. Shimizu, *T. Hosoya

Chem. Commun. 2015, 51, 16613.

https://doi.org/10.1039/C5CC07463K

Selected as inside back cover; Highlighted in Chemistry View

Concise Synthesis of v-Coelenterazines

41

*T. Hosoya, R. Iimori, S. Yoshida, Y. Sumida,

Y. Sahara-Miura, J.-i. Sato, S. Inouye

Facile Synthesis of Diverse Multisubstituted ortho-Silylaryl Triflates via C–H Borylation

40

S. Yoshida, K. Shimomori, T. Nonaka, *T. Hosoya

Chem. Lett. 2015, 44, 1324.

https://doi.org/10.1246/cl.150535

Open Access

An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether

39

S. Yoshida, Y. Hazama, Y. Sumida, T. Yano,

*T. Hosoya

Molecules 2015, 20, 10131.

https://doi.org/10.3390/molecules200610131

Special Issue: Development and Application of Aryne Chemistry in Organic Synthesis; Open Access

Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

38

S. Morooka, M. Hoshina, I. Kii, T. Okabe, H. Kojima, N. Inoue, Y. Okuno, M. Denawa, S. Yoshida, J. Fukuhara, K. Ninomiya, T. Ikura, T. Furuya, T. Nagano, K. Noda, S. Ishida, T. Hosoya, N. Ito, N. Yoshimura, and *M. Hagiwara

Mol. Pharmacol. 2015, 88, 316.

https://doi.org/10.1124/mol.114.097345

Generation of cycloheptynes and cyclooctynes via a sulfoxide–magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates

37

S. Yoshida, F. Karaki, K. Uchida, *T. Hosoya

Chem. Commun. 2015, 51, 8745.

https://doi.org/10.1039/C5CC01784J

Selected as inside front cover

Generation of Arynes Using Trimethylsilylmethyl Grignard Reagent for Activation of ortho-Iodoaryl or ortho-Sulfinylaryl Triflates

36

S. Yoshida, K. Uchida, *T. Hosoya

Chem. Lett. 2015, 44, 691.

https://doi.org/10.1246/cl.150060

Open Access

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

35

M. Yoshida, N. Kataoka, K. Miyauchi, K. Ohe, K. Iida, S. Yoshida, T. Nojima, Y. Okuno, H. Onogi, T. Usui, A. Takeuchi, T. Hosoya, T. Suzuki, *M. Hagiwara

Proc. Natl. Acad. Sci. USA  2015, 112, 2764

https://doi.org/10.1073/pnas.1415525112


Substituted 5,6,11,12-Tetradehydrodibenzo[a,e]cyclooctenes: Syntheses, Properties, and DFT Studies of Substituted Sondheimer–Wong Diynes

34

F. Xu, L. Peng, K. Shinohara, T. Morita, S. Yoshida,

T. Hosoya, *A. Orita, J. Otera

J. Org. Chem. 2014, 79, 11592.

https://doi.org/10.1021/jo502248p

An Efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

33

S. Yoshida, K. Uchida, K. Igawa, K. Tomooka, *T. Hosoya

Chem. Commun. 2014, 50, 15059.

https://doi.org/10.1039/C4CC07058E

Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper

32

*S. Yoshida, Y. Hatakeyama, K. Johmoto, H. Uekusa,

*T. Hosoya

J. Am. Chem. Soc. 2014, 136, 13590.

https://doi.org/10.1021/ja507660x

Highlighted in Nature Chem., Organometallic News,

and Org. Chem. Highlights

Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide–aryne and azide–alkyne cycloadditions

31

S. Yoshida, T. Nonaka, T. Morita, *T. Hosoya

Org. Biomol. Chem. 2014, 12, 7489.

https://doi.org/10.1039/C4OB01654H

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

30

M. Yamamoto, H. Onogi, I. Kii, S. Yoshida, K. Iida,

H. Sakai, M. Abe, T. Tsubota, N. Ito, T. Hosoya,

*M. Hagiwara

J. Clin. Investig. 2014, 124, 3479.

https://doi.org/10.1172/JCI73805

Formal C–H-Azidation-Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes

29

S. Yoshida, Y. Misawa, *T. Hosoya

Eur. J. Org. Chem. 2014, 3991

https://doi.org/10.1002/ejoc.201402516

Generation of Arynes Triggered by the Sulfoxide–Metal Exchange Reaction of ortho-Sulfinylaryl Triflates

28

S. Yoshida, K. Uchida, *T. Hosoya

Chem. Lett. 2014, 43, 116.

https://doi.org/10.1246/cl.130899

Open Access

Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions

27

*S. Inouye, J.-i. Sato, Y. Sahara–Miura, S. Yoshida,

H. Kurakata, *T. Hosoya

Biochemi. Biophys. Res. Commun. 2014, 445, 157.

https://doi.org/10.1016/j.bbrc.2014.01.133

A New Organic Two-Electron Oxidant: 9,10-Diaryl-9,10-dihydroanthracene-9,10-bis(ylium)

26

*J. Ichikawa, H. Tanabe, S. Yoshida, T. Kawai, M. Shinjo, T. Fujita

Chem. Asian J. 2013, 8, 2588.

https://doi.org/10.1002/asia.201300710

Development of bis-unsaturated ester aldehydes as amino-glue probes: Sequential double azaelectrocyclization as promising strategy for bioconjugation

25

*K. Tanaka, Y. Nakamoto, E. R. O. Siwu, A. R. Pradipta, K. Morimoto, T. Fujiwara, S. Yoshida, T. Hosoya, Y. Tamura, G. Hirai, M. Sodeoka, *K. Fukase

Org. Biomol. Chem. 2013, 11, 7326.

https://doi.org/10.1039/C3OB41507D

C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase

24

*S. Inouye, J.-i. Sato, Y. Sahara–Miura, S. Yoshida,

H. Kurakata, *T. Hosoya

Biochem. Biophys. Res. Commun. 2013, 437, 23.

https://doi.org/10.1016/j.bbrc.2013.06.026

Synthesis of diverse aromatic oxophosphorus compounds by the Michaelis–Arbuzov-type reaction of arynes

23

S. Yoshida, *T. Hosoya

Chem. Lett. 2013, 42, 583.

https://doi.org/10.1246/cl.130116

Open Access

Copper-Catalyzed Extended Pummerer Reactions of Ketene Dithioacetal Monoxides with Alkynyl Sulfides and Ynamides with an Accompanying Oxygen Rearrangement

22

K. Murakami, J. Imoto, H. Matsubara, S. Yoshida,

*H. Yorimitsu, *K. Oshima

Chem. Eur. J. 2013, 23, 5625.

https://doi.org/10.1002/chem.201204072

Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: Comparison of substrate specificity for C2-modified coelenterazines

21

*S. Inouye, Y. Sahara–Miura, J.-i. Sato, R. Iimori,

S. Yoshida, *T. Hosoya

Protein Expr. Purif. 2013, 88, 150.

https://doi.org/10.1016/j.pep.2012.12.006

Nucleophilic Substitution Reaction at the Nitrogen of Arylsulfonamides with Phosphide Anion

20

S. Yoshida, K. Igawa, *K. Tomook

J. Am. Chem. Soc. 2012, 134, 19358.

https://doi.org/10.1021/ja309642r

Highlighted in ChemASAP

Palladium-Catalyzed Regio- and Stereoselective Hydrosilylation of Electron-Deficient Alkynes

19

*Y. Sumida, T. Kato, S. Yoshida, *T. Hosoya

Org. Lett. 2012, 14, 1552.

https://doi.org/10.1021/ol300279c

Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation

18

D. Sakai, I. Kii, K. Nakagawa, H. N. Matsumoto, M. Takahashi, S. Yoshida, T. Hosoya, K. Takakuda, *A. Kudo

Enhanced clickability of doubly sterically-hindered aryl azides

17

S. Yoshida, A. Shiraishi, K. Kanno, T. Matsushita,

K. Johmoto, H. Uekusa, *T. Hosoya

Sci. Rep. 2011, 1, 82.

https://doi.org/10.1038/srep00082

Open Access

Intermolecular Reductive Radical Addition to 2-(2,2,2-Trifluoroethylidene)-1,3-dithiane 1-Oxide: Experimental and Theoretical Studies

16

R. Nakayama, H. Matsubara, D. Fujino, T. Kobatake,

S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2010, 12, 5748.

https://doi.org/10.1021/ol1025926


Synthesis of 3-Trifluoromethylbenzo[b]furans from Phenols via Direct Ortho Functionalization by Extended Pummerer Reaction

15

T. Kobatake, D. Fujino, S. Yoshida, *H. Yorimitsu,

*K. Oshima

J. Am. Chem. Soc. 2010, 132, 11838.

https://doi.org/10.1021/ja1030134

Highlighted in Synfacts and Org. Proc. Res. Dev.

Strain-promoted double-click reaction for chemical modification of azido-biomolecules

14

I. Kii, A. Shiraishi, T. Hiramatsu, T. Matsushita, H. Uekusa,

S. Yoshida, M. Yamamoto, A. Kudo, M. Hagiwara, *T. Hosoya

Org. Biomol. Chem. 2010, 8, 4051.

https://doi.org/10.1039/C3OB41507D

Selected as inside front cover.

Reaction of 2-(2,2,2-Trifluoroethylidene)-1,3-dithiane 1-Oxide with Ketones under Pummerer Conditions and Its Application to the Synthesis of Trifluoromethyl-Substituted Five-Membered Heteroaromatics

13

T. Kobatake, S. Yoshida, *H. Yorimitsu, *K. Oshima

Angew. Chem., Int. Ed. 2010, 49, 2340.

https://doi.org/10.1002/anie.200906774

Highlighted in Org. Proc. Res. Dev.

Tin-Hydride-Mediated Radical Addition of Alkyl Halides to 2-Methylene-1,3-dithiane Monoxide as a Ketene Equivalent

12

S. Yoshida, *H. Yorimitsu, *K. Oshima

Heterocycles 2010, 80, 259.

https://doi.org/10.3987/COM-09-S(S)6

Palladium-catalyzed Mizoroki–Heck Reactions of 2-Methylene-1,3-dithiane 1-Oxide with Aryl Iodides

11

E. Morita, M. Iwasaki, S. Yoshida, *H. Yorimitsu,

*K. Oshima

Chem. Lett. 2009, 38, 624.

https://doi.org/10.1246/cl.2009.624

2-(2,2,2-Trifluoroethylidene)-1,3-dithiane Monoxide as a Trifluoromethylketene Equivalent

10

S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2009, 11, 2185.

https://doi.org/10.1021/ol9004883

Highlighted in Synfacts

Radical Addition of Alkyl Halides to 2-Methylene-1,3-dithiane Monoxide as a Ketene Equivalent

9

S. Yoshida, *H. Yorimitsu, *K. Oshima

Chem. Lett. 2009, 8, 248.

https://doi.org/10.1246/cl.2009.248

2-Alkylidene-1,3-dithiane Monoxides as Activated Alkenes in Rhodium-Catalyzed Addition Reaction of Arylboronic Acids

8

S. Yoshida, *H. Yorimitsu, *K. Oshima

Heterocycles 2008, 76, 679.

https://doi.org/10.3987/COM-08-S(N)65

Synthesis of Bulky Arylphosphanes by Rhodium-Catalyzed Formal [2+2+2] Cycloaddition Reaction and Their Use as Ligands

7

T. Kobatake, A. Kondoh, S. Yoshida, *H. Yorimitsu,

*K. Oshima

Chem. Asian J. 2008, 3, 1613.

https://doi.org/10.1002/asia.200800102

Extended Pummerer Reaction of Arylketene Dithioacetal Monoxides with Aromatic Compounds by Means of Trifluoromethanesulfonic Anhydride

6

S. Yoshida, *H. Yorimitsu, *K. Oshima

Chem. Lett. 2008, 37, 786.

https://doi.org/10.1246/cl.2008.786

Synthesis of Benzo[b]thiophenes by Cyclization of Arylketene Dithioacetal Monoxides under Pummerer-like Conditions

5

S. Yoshida, *H. Yorimitsu, *K. Oshima

Org. Lett. 2007, 9, 5573.

https://doi.org/10.1021/ol702643j


Zirconocene-Catalyzed Alkylative Dimerization of 2-Methylene-1,3-dithiane via a Single Electron Transfer Process to Provide Symmetrical vic-Bis(dithiane)s

4

S. Yoshida, *H. Yorimitsu, *K. Oshima

J. Organomet. Chem. 2007, 692, 3110.

https://doi.org/10.1016/j.jorganchem.2006.12.029

Rhodium-Catalyzed Addition of Arylboronic Acids to 2-Methylene-1,3-dithiane Monoxide

3

S. Yoshida, *H. Yorimitsu, *K. Oshima

Synlett 2007, 1622.

https://doi.org/10.1055/s-2007-980373

Naphthalene-1,8-diylbis(diphenylmethylium) as an Organic Two-Electron Oxidant: Benzidine Synthesis via Oxidative Self-Coupling of N,N-Dialkylanilines

2

T. Saitoh, S. Yoshida, *J. Ichikawa

J. Org. Chem. 2006, 71, 6414.

https://doi.org/10.1021/jo060662s


1,8-Bis(diphenylmethylium)naphthalenediyl Dication as an Organic Oxidant: Synthesis of Benzidines via Self-Coupling of N,N-Dialkylanilines

1

T. Saitoh, S. Yoshida, *J. Ichikawa

Orga. Lett. 2004, 6, 4563.

https://doi.org/10.1021/ol048058w

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